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The podocytes are the largest cells in the glomerulus, have many primary processes which terminate in numerous secondary processes surrounding the capillaries, and finally are divided into foot processes

Grove, G.L., Kligman, A.M

Significant transcriptomic alterations were first identified in skeletal muscle of MASLD models

While the analogy isn't perfect, it captures the essence of why researchers often prefer localized protocols for joint-specific studies

Biochem 2006, 141 (3), 301307

As with any peptide or hormone-based treatment, side effects such as nausea, increased freckles or mole changes, and flushing can occur