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A 25-trial meta-analysis found an average loss of 3.7 kg ( 8 lbs) roughly 34 % of starting body weight over 852 weeks compared with placebo (PubMed 2024)

Articles were excluded if they were not written in the English language, did not have a registered digital object identifier (DOI), were a letter to the editor or an abstract-only publication, did not directly assess the use of GLP-1 RAs in psoriasis or HS, were duplicate studies, or were inaccessible through institutional resources

Oxidative stress triggers lipid droplet accumulation in primary cultured hepatocytes by activating fatty acid synthesis

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