Abstract G protein-coupled receptors (GPCRs) are integral membrane proteins which closely interact with their plasma membrane lipid microenvironment
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Glu, the predominant excitatory neurotransmitter, induces neuronal hyperexcitability through its interaction with ionotropic receptors, such as AMPA, NMDA, and kainate, and metabotropic receptors, known as mGluRs [3]