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The dismutation of superoxide can also occur spontaneously, but such reaction is 10 4 times slower than the enzymatic dismutation by SOD2

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A 2022 editorial review by Sikiric and colleagues in World Journal of Gastroenterology synthesized prior rat work on major vessel occlusion, Pringle-maneuver ischemia-reperfusion, and Budd-Chiari syndrome, framing collateral-vessel recruitment as a proposed mechanism by which BPC-157 may compensate for occluded flow a narrative synthesis that does not itself report original effect sizes or p-values

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Generally, the benefits can last from several days to a few weeks, and regular maintenance injections may be recommended for sustained results