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Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism

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The researchers identified the bacterial caseinolytic protease (ClpP) as the ADEP target, demonstrating that ADEPs bind to ClpP, activate the otherwise inactive Clp-protease complex, and disrupt essential bacterial protein regulation, potentially accounting for their potent antibacterial effects

British Journal of Pharmacology, 151(6), 737-748

( B ) Influence of MPST depletion on the luminescence recorded from APEX2-expressing HeLa cells after addition of H 2 O 2 (50 M) (left panel)