Intravenous ifosfamide/mesna is associated with depletion of plasma thiols without depletion of leukocyte glutathione
TrxR1 is predominantly a cytoplasmic enzyme [52], while TrxR2 is mitochondrial [53]
MRP1/GS-X pump ATPase expression: is this the explanation for the cytoprotection of the heart against oxidative stress-induced redox imbalance in comparison to skeletal muscle cells
Some practitioners run continuous protocols, but cycling remains the conservative approach until more long-term data exists
A Cochrane systematic review of NAC for COPD exacerbations (39 RCTs, n=7,436) found that NAC and other mucolytics significantly reduced the frequency of acute exacerbations (OR 0.75, 95% CI 0.62-0.92) (Poole et al., Cochrane Database Syst Rev, 2019) [43]
Numerous research efforts have focused on exploring the mechanism of endogenous antioxidants as well as developing specific exogenous antioxidants [77,78,79]