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1 Introduction Incretin peptides are secreted from the intestine after nutrient ingestion and enhance glucose-stimulated insulin secretion ( 2 Weight loss pharmacotherapies 2.1 GLP-1R and GIPR agonism reduce body weight in patients with obesity Early GLP-1R agonists were approved to treat T2D ( The mechanism underlying the impressive weight loss potential of GLP-1R agonists is primarily, if not exclusively, mediated by a reduction in energy intake

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Ackermann (Nikon Imaging Center at the University of Heidelberg) for providing microscope access and assistance

Neunzig, I

These various processes contribute to the development of OA by promoting a proinflammatory, catabolic state accompanied by increased susceptibility to cell death that together lead to increased joint tissue destruction and defective repair of damaged matrix

Important for inflammatory response