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These patterns act as ligands for pattern recognition receptors (PRRs) expressed on the microglial surface, most notably Toll-like receptors 2 and 4 (TLR2 and TLR4) and triggering receptor expressed on myeloid cells 2 (TREM2) [54]

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EGF at roughly 6,000 Da, PDRN as a polymeric mixture, and hyaluronic acid above 50 kDa cannot