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If youre on GLP-1 for cardiovascular risk reduction per the SELECT indication, the protective effect requires continuous dosing

Liraglutides mechanism involves appetite suppression, which leads to reduced energy intake and clinically relevant weight loss (Feinglos et al., 2005

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Moreover, because the TMD is less accessible than the extracellular region, this approach may facilitate the design of peptide ligands with moderate binding to better distinguish between target cells and nontarget cells

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