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Improvements in Endothelial Dysfunction Among the most significant outcomes was the improvement in endothelial function, demonstrated by an increase in flow-mediated dilation (FMD) and a reduction in asymmetric dimethylarginine (ADMA), a known endogenous inhibitor of nitric oxide synthase and marker of endothelial dysfunction

In obesity, excessive fat accumulation leads to chronically elevated leptin levels without adequate regulatory feedback, resulting in leptin resistance

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Specific clinical trials in pregnant women have not been conducted, as it is not ethically justifiable to test medication in this way

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Conforme o seu princpio ativo, os medicamentos GLP-1 podem ser indicados pelo mdico para ajudar no tratamento da diabetes tipo 2, do excesso de peso e da obesidade