These results indicated that GHK decreases AQP4 expression via miR-146a-3p through the PI3K/Akt pathway (Figure 7)
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Moreover, IHC analysis of filaggrin and loricrin, key proteins involved in epidermal barrier function, revealed that glutathione amino acid precursors treatment enhanced their levels in UVB-exposed skin, supporting the protective effects of glutathione amino acid precursors on barrier function
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