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Abstract Background Glutathione transferases (GSTs) belong to the family of Phase II detoxification enzymes

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The following table is a guide for the initial daily dose of valproic acid (15 mg/kg/day): 2.2 General Dosing Advice Dosing in Elderly Patients Due to a decrease in unbound clearance of valproate and possibly a greater sensitivity to somnolence in the elderly, the starting dose should be reduced in these patients