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Cholecalciferol is metabolized to its active form, calcitriol, which increases the body's absorption of calcium and phosphorus

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This approach aims to attenuate these responses and leverage a potential metabolic advantage (higher energy expenditure), particularly in insulin-resistant states, while helping to recalibrate the homeostasis of the brains hungersatiety circuits

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doi: 10.1038/s41467-018-06812-y 52 SmithALWhitehallJCBradshawCGayDRobertsonFBlainAPet al

This creates a robust cellular environment, allowing all other metabolic processes to function more effectively