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By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis, thereby activating SIRT1 (Sirtuin 1) pathways associated with mitochondrial biogenesis and fat oxidation

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486 The axon damages caused by SARM1 or NMNAT2 can be restored by increasing NAD + synthesis, like over-expressing the NMNAT2 enzyme

The interplay of gut microbiota, obesity, and depression: insights and interventions