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An Evaluation of Dirlotapide to Reduce Body Weight of Client-Owned Dogs in Two Placebo-Controlled Clinical Studies in Europe

The medication is eliminated primarily through proteolytic degradationmeaning it is broken down by enzymes into smaller peptide fragments and amino acids, which are then processed through normal metabolic pathways

10.1186/s12967-022-03272-3 132 OzakiT.YoshinoY.TachibanaA.ShimizuH.MoriT.NakayamaT.et al

Data Animal Data In pregnant rats given twice weekly subcutaneous doses of 0.02, 0.1, and 0.5 mg/kg tirzepatide [0.03-, 0.07-, and 0.5-fold the maximum recommended human dose (MRHD) of 15 mg once weekly based on AUC] during organogenesis, increased incidences of external, visceral, and skeletal malformations, increased incidences of visceral and skeletal developmental variations, and decreased fetal weights coincided with pharmacologically-mediated reductions in maternal body weights and food consumption at 0.5 mg/kg

Ann Diagn Pathol 8:207212 Woessmann W, Neugebauer M, Gossen R et al (2003) Successful chemotherapy for malignant neuroectodermal tumor of infancy