constipation and glp 1 Why Matters While on GLP-1/GIP-1 Medications Constipation is a common sometimes underappreciated side effect of GLP-1 and GIP-1 agonists like semaglutide (Wegovy®) or tirzepatide (Zepbound®). Left untreated, it can lead Constipation and GLP-1 Medications: What

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It may increase energy expenditure by upregulating uncoupling protein-2 (142, 143) and downregulating genes associated with fat storage and differentiation, such as PPAR and SREBP-1c (126, 142)

Chemically modified GIP analogues have shown some glucose-lowering activity in hyperglycaemic rodent models, but they have not been tested in patients with type 2 diabetes

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