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This effort led to the development of Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide), a key focus of this study [2]

References McCoy AT, Benoist CC, Wright JW, Kawas LH, Bule-Ghogare JM, Zhu M, Appleyard SM, Wayman GA, Harding JW

Initial efforts involved synthesizing AngIV analogs with extended half-lives by incorporating reduced peptide bonds between residues, as exemplified by Divalinal-AngIV and Norleural-AngIV

Binding studies employed tritiated small molecule HGF analogs to map the distribution of HGF/c-Met receptors in the brain, establishing a correlation with known AT4 receptor densities

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