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Elevated levels of cholesterol carried by apolipoprotein B (apoB) (non-high-density lipoprotein cholesterol [HDL-C] and low-density lipoprotein-C [LDL-C]) is a root cause of atherosclerosis and reducing levels of atherogenic cholesterol lowers atherosclerotic cardiovascular disease (ASCVD) risk [12]

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Individuals with contraindications-including personal or family history of medullary thyroid carcinoma or MEN 2-are not candidates for this medication