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In eight CVOTs history of heart failure was reported at baseline and it ranged from 9% to 24% with no significant difference between patients receivng GLP-1 receptor agonist and patients receiving placebo

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Preclinical studies has demonstrated that liraglutide enhances NK cell-mediated anti-tumor immune responses by inhibiting the IL-6/STAT3 signaling pathway in hepatocellular carcinoma cells and enhances NK cell functionality in obese patients [91]

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Successful compliance depends on concordance shared decision making so that a suitable management plan can be put in place