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In pivotal trials, weekly semaglutide produced roughly 1415% body-weight reduction at 68 weeks (STEP 1, NEJM 2021), and tirzepatide a dual GIP/GLP-1 co-agonist reached 1822% at one year (SURMOUNT-1, NEJM 2022)

However, their prolonged use can lead to various adverse side effects

Dutta, S., Kumar, T., Singh, S., Ambwani, S., Charan, J., & Varthya, S

Levels below 70 g/L are considered inadequate and can potentially hinder thyroid hormone metabolism and antioxidant protection, while normal blood Se levels are often seen in the 70150 g/L range [4]

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