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Further to this, local guidelines may not always directly align to KDIGO and ADA guidelines

Compared to fission, mitochondrial fusion is regulated by mitochondrial fusion proteins 1/2 (Mfn1/2) and optic atrophy 1 (OPA1), which control the fusion of the inner mitochondrial membrane (IMM) and outer mitochondrial membrane (OMM), respectively (50)

Any insights on how they compare on safety side

None of these signs are definitive on their own

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