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After a therapeutic dose, APAP is mostly converted to pharmacologically inactive glucuronide (APAP-gluc, 5257% of urinary metabolites) and sulfate (APAP sulfate, 3044%) conjugates, with a minor fraction being oxidized to a reactive metabolite NAPQI (510%) (Figure 1)

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The manufacturer advises against use during breastfeeding due to insufficient human data, though animal studies have not shown concerning levels of transfer

It may inhibit the production of melanin, the pigment responsible for skin color, leading to a more even and brighter complexion

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