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Given these single-agent efficacy profiles and the lack of comparative benefit data for combinations, current clinical consensus favors optimizing GLP-1 dosing before considering additional agents

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Kwang-Chul Kwon and McCarthy

This article looks at what the research actually supports, where the reasoning is extrapolation rather than evidence, and why the format the two are supplied in genuinely matters

Takahashi K, Kantarjian HM, Ravandi F, Garcia-Manero G, Borthakur G, Kadia TM, Dinardo CD, Jabbour E, Konopleva M, Andreeff M , Cortes JE