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Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr(682)-phosphorylated APP CTF

Impaired mitochondrial function in dopaminergic neurons in the substantia nigra can lead to increased oxidative stress, neuronal damage, and neuronal death, contributing to PD progression [20]

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Erastin was reported to cause cancer cells to perish via undetermined mechanisms in 2003 [23]

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Epidermal growth factor receptor (EGFR) is a highly expressed tyrosine kinase receptor in the liver, and its ligands are direct mitogens for hepatocytes [77]