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For example, reactive microglia phagocyte pathogens and cellular debris, reactive astrocytes limit damage by erecting barriers to spread of inflammation and, together with the oligodendroglial lineage cells responsible for remyelinating axons, support postlesional regeneration
Although further dose-optimization studies are warranted to maximize the antiviral effect in the lower respiratory tract, phenformin showed antiviral activity in the upper respiratory tract, the main anatomic site for viral entry and spread
Here we present the oxygen-to-sulfur exchange strategy, that transforms traditional carboxamides to thioamides, yielding electrophilic warheads, including chlorothioacetamides and fluorothioacetamides, with enhanced cysteine reactivity, while retaining aqueous stability and selectivity
Im plus-plus
Importantly, G b can be directly related to differences in dissociation constants (K I ), while G can be converted into k inact values, providing a direct link between calculated parameters and experimentally measured inhibition kinetics
