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Montgomery, The University of Melbourne, Australia Reviewed by Christelle Le Foll, University of Zurich, Switzerland

These patients are often recommended to receive 1 mg of oral vitamin B12 daily indefinitely, but intramuscular injections may be necessary if oral supplementation is insufficient Mahawar2018Langan2017

Some off-label prescribing should be expected: in the UK, liraglutide has an indication for weight loss only, but NICE guidelines list it as a treatment option for type 2 diabetes [59]

In the multiple ascending dose groups, weight loss persisted for up to 150 days after the final dose [8]

Given the strong association between HS, obesity, and metabolic syndrome, these agents may offer therapeutic benefit through their anti-inflammatory and metabolic effects

The big change is the way both fit to opioid receptors