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70 For example, compound 2j, a triazole-containing derivative, has demonstrated high potency and comparable efficacy to danuglipron in preclinical studies, suggesting it could serve as a lead compound for further development

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Mcanisme d'action : cascade mlanocortine cAMP/PKA/MITF Activation prsynaptique MC1R cutan et centrale MC3R/MC4R/MC5R VOIE PRIMAIRE MLANOGENSE MC1R sur mlanocytes Liaison de haute affinit au rcepteur MC1R sur les mlanocytes pidermiques