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SowahSARiedlLDamms-MachadoAJohnsonTSSchbelRGrafMet alEffects of weight-loss interventions on short-chain fatty acid concentrations in blood and feces of adults: a systematic review

[18] suggested that although GLP-1 RAs were related to a transient worsening of DR because of the rapid improvement in glycemic control, 71% of diabetes patients showed improvement of DR after continuing GLP-1 RAs treatment

They do have known potential side effects ranging from mild nausea and constipation to severe gastroparesis with vomiting, intestinal obstruction, and pancreatitis

This matters because blood sugar swings can directly impact appetite

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