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Novo Nordisks semaglutide compound, under the brand name Ozempic, is designed to act in the body similarly to the hormone glucagon-like peptide 1 (GLP-1)

When the medication is withdrawn, these receptors are no longer stimulated, and appetite-regulating hormones return to their baseline stateor potentially to levels that promote increased food intake as the body attempts to restore lost weight

Under ad libitum feeding conditions, we found that heart, body, and heart/body weights and nonfasting tail blood glucose measurements were not affected by treatment assignment (Supplemental Figure 1

The body may adapt to the drug over time, so these side effects may become more bearable or go away completely

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