Myeloproliferative neoplasms (such as polycythaemia vera or chronic myeloid leukaemia) and acute leukaemias can increase B12-binding proteins (transcobalamins), raising total serum B12
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The disruption of the EG has also been identified in diabetic nephropathy and retinopathy, and it plays a role in their development (47, 48)
However, extant human studies on BPC-157 as an anti-ulcer agent indicate a positive safety profile, with no toxicity reported [34]