17 Given that WC is a critical determinant of WHtR, the pronounced decrease in WC among semaglutide-treated patients suggests a likely improvement in WHtR and, by implication, cardiometabolic health
Mutations in these genes not only cause severe obesity but also frequently lead to a broad spectrum of neurological phenotypes, including intellectual disability, developmental delay, and behavioral abnormalities (e.g., autism-like features), highlighting the foundational role of hypothalamic development in energy homeostasis [12,14]
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they shorten with every cell division, and this shortening is directly linked to aging and disease