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study in Gastroenterology remains the foundational paper supporting KPV as one of the leading peptides for gut health via its oral delivery mechanism, demonstrating PepT1-mediated transport in Caco-2 cell models and murine colitis models with measurable reductions in colonic inflammation

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However, when these cellular defenses become overwhelmed by chronic inflammation, viral persistence, or environmental triggers, they can create symptoms throughout the entire body

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demonstrated the specific protective effect of Tongxieyaofang polysaccharide in mitigating TRP metabolism disorders induced by CUS ( Cheng et al