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Description

Canakinumab: a human anti-IL-1beta monoclonal antibody for the treatment of cryopyrin-associated periodic syndromes

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Materials and methods Animals and treatments Two months old SPF grade SD male rats were acquired from Henan Laboratory Animal Center (SYXK 2018-0005)

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The mutation in ALDH4A1 leads to the accumulation of pyrroline-5-carboxylate (P5C) in the mitochondria, which can react with PLP to cause PLP deficiency in the brain and can also be converted to proline, resulting in elevated plasma proline levels (Fig

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