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The most reported adverse effect upon injection of a biologic drug is an injection site reaction

Surgery can leave scars, and some people are not healthy enough to have surgery

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Enteropathy (leaky gut syndrome) with increased intestinal permeability and intraepithelial lymphocyte infiltration may also increase the risk for developing thyroid autoimmunity, but further studies are needed (61)

So overall, they're not as safe

Patients taking Tradjenta 5mg will typically be able to lower their A1C scores although it can take several weeks on the medication to start seeing these results