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Duration of studies ranged from 3 months to 3 years, and one study found that significant benefits were only seen with a duration of at least 6 months

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In colonic tissue models, gabapentin was associated with: Reduced mast cell density or activation markers Decreased release of inflammatory mediators Improvement in visceral pain signaling These findings suggest gabapentin may exert indirect mast cellregulating effects within colonic tissue in experimental models

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