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A 2023 study in the journal Diabetes, Obesity and Metabolism examined hormonal changes in men on semaglutide and found improvements in testosterone levels that were partially, but not entirely, explained by weight loss alone

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7 Unresolved questions in the GLP-1 era 7.1 Durability of benefit and the problem of treatment discontinuation A major unresolved question is whether the symptomatic and functional gains associated with GLP-1 receptor agonists in obesity-related KOA can be maintained over the long term