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In the obese trial cohort, 1 mg moved 24-hour heart rate by +0.7 bpm in the first week, essentially placebo. In a healthy lean Phase 1b group, the same dose raised heart rate by about 10 bpm, with a peak near 15 to 20 bpm around days 4 to 6. Lean, younger participants had more reactive heart-rate control than the sedentary, obese, and metabolically stressed trial population
M., Tripodi, F., Rossi, R., Navarro-Cremades, F
Hunter Date: November 1, 2015 Event: Theatrical Performance" "Pocatello" Location: Mathers Theatre, Dickinson College Russell Sayer Williams "Pocatello" by Samuel D
Theranostics 8 , 50395058 (2018)
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