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In the perioperative management of patients taking SGLT2 inhibitors, the optimal approach for preventing EDKA is to withhold the medication in any setting where predisposing factors for ketoacidosis are present (e.g

However, people without gallbladders may experience more pronounced digestive side effects when starting GLP-1 therapy because their bile flow is already compromised and semaglutide adds another layer of digestive slowing

This greatly reduces the risk of allergic reactions or rejection

These insights help explain why one person thrives with high-intensity exercise while another requires a gentler approach

doi: 10.3389/fendo.2019.00933 19 HalliwellBGutteridgeJM

Nov 7 2025;doi:10.1056/NEJMoa2513032