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Reports also indicate that there has been a simultaneous increase in the financial burden of disease, including trillions spent on healthcare resources by governments worldwide (predominantly in developing countries) to address health concerns

Pain 155(2):269274 Ben Aissa M, Tipton AF, Bertels Z, Gandhi R, Moye LS, Novack M, Bennett BM, Wang Y, Litosh V, Lee SH, Gaisina IN, Thatcher GR, Pradhan AA (2018) Soluble guanylyl cyclase is a critical regulator of migraine-associated pain

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