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This structural adjustment has been explored for its potential to retain certain functional properties of FOXO4 while exhibiting a longer stability profile in research settings

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doi: 10.1097/prs.0000000000007783 7 SchaverienMVAsaadMSelberJCLiuJChenDNHallMSet al

In Drosophila melanogaster , reducing 3- O sulfation causes Notch-associated neurogenic phenotypes and lower levels of Notch protein 56