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121,122 Ji et al found that oral administration of TMAO significantly exacerbated demyelination in spontaneously hypertensive rats, with the underlying mechanism possibly related to TMAO-induced pyroptosis of oligodendrocytes and inflammation

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Cytokine array The cytokine assay was performed using a Proteome Profiler Mouse Cytokine Array Kit (R and D systems, Minneapolis, MN, USA )