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If proper titration starting at the lowest dose with gradual 4-week escalation still produces intolerable GI effects, split dosing may allow continued use of the medication rather than abandoning it entirely

At 20mg/mL: 3mg = 15 units, 6mg = 30 units, 10mg = 50 units

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A meta-analysis published in PMC concluded that weight regain is common and drug-dependent following discontinuation of anti-obesity pharmacotherapies, emphasising the need for sustained, long-term treatment strategies to manage obesity as a chronic disease

Retatrutide VS Eloralintide Two Next-Generation Obesity Therapies from Eli Lilly