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Straining due to constipation or frequent bowel movements from diarrhea can increase pressure on rectal veins, leading to hemorrhoids or aggravating existing ones

Though none of the studies have looked at a population at high risk of kidney outcomes, there is a consistent drumbeat of improved renal surrogate outcomes (Figure 8)

New Engl J Med 384 , 9891002 (2021)

The effect of oral ferrous sulfate use in different posology on laboratory values and clinical findings related to iron metabolism in anemia due to iron deficiency

Therefore, after a thorough risk-benefit analysis, the decision was made to withhold adjuvant radiotherapy, with the fully informed consent of the patient and his family