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They both require pyridoxal-5-phosphate, the active form of vitamin B6, as a cofactor for their enzymatic activity [26, 27, 28]

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A second enzyme, histamine N-methyltransferase (HNMT), handles histamine produced within cells throughout the body

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That is why they are more accurately viewed as metabolic and satiety-regulating medications, not simple appetite suppressants

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2025 Oct 29

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Tesofensine also increased blood pressure, heart rate, and frequency of mood changes

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