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Their use is rising rapidly, and with good reason: These medications have been shown to reduce blood sugar, improve fatty liver, GERD, sleep apnea, osteoarthritis, blood pressure, triglycerides, major adverse cardiovascular events, and even show potential benefits for conditions like alcohol use disorder (Mozaffarian et al., 2025

The economic burden of obesity is also substantial, helping drive higher health care costs and lost productivity

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Ngamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site

doi: 10.1155/2021/9968228

Common mechanisms of ferroptosis including iron overload, lipid peroxidation, GPX4 inhibition, and system Xc inhibition in obesity, which lead to decrease of GSH, increased ROS, and even ferroptosis