To put that in perspective, the approved GLP-1 drugs achieved less weight loss in longer timeframes: for example, semaglutide (Wegovy) averages about 15% weight loss over ~16 months, and tirzepatide (Zepbound) achieved around 22.5% at 72 weeks in trials
The low cost and easy use may tempt some, but theres no FDA approval, no clinical backing, and many reviews report little to no results
Final Takeaway: Retatrutide Looks Promising, But Approval Matters Retatrutide has created major interest because trial results showed significant weight loss
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These morphological changes are often attributed to chronic hyperglycaemia-induced oxidative stress and neuroinflammation