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doi:10.1007/s40268-015-0119-3 Effectiveness of Epidural Steroid Injections Available research indicates generally favorable results, with 70% to 90% of patients experiencing pain relief from these injections, lasting for a week to a year

Lindemans, J

A lot of people are doing this, and gosh, the placebo effect is definitely part of it, but its also real

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More specifically, it interacts with serotonin receptors (5-HT1A/5-HT2), dopamine receptors, GABA balance, and the nitric oxide system