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Cravings fade because your blood sugar stops spiking and crashing

The FDA approved tirzepatide (as Mounjaro for diabetes and Zepbound for obesity) with a starting dose of 2.5 mg weekly

GLP-1RAs demonstrated a favorable safety profile, with no meaningful increase in severe hypoglycemia or acute pancreatitis observed across trials

At the very least, it is worth noting that they were probably designed to have the best chance of showing benefit

Animals developed persistent esophagitis with hemorrhagic lesions, thinned epithelium, and chronically reduced sphincter pressures lasting up to 20 months

It blocks the reabsorption of norepinephrine and serotonin in your brain