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from a systems-neuroscience perspective, the earliest failure is not metabolic in isolation but a collapse of precision control- the brains ability to assign reliable confidence to prediction errors across hierarchical levels
Access this article References Bocci V, Aldinucci C, Mosci F, Carraro F, Valacchi G (2007) Ozonation of human blood induces a remarkable upregulation of heme oxygenase-1 and heat stress protein-70
Oxidant-induced lung epithelial cell tolerance: the role of intracellular glutathione and NF-B
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Heres a post from December explaining this
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