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Additionally, it enhanced NO production and eNOS phosphorylation, suggesting that the eNOS/NO pathway plays a crucial role in its cardioprotective mechanism (Chan et al., 2011)

Informing patients on potential side effects, gradual dose escalation, and contraindications is essential to ensure safety and adherence

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Patients should never increase their dose more rapidly than recommended, even if they are tolerating the current dose well, as this significantly increases the risk of adverse effects